Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils.

@article{Niiro1997RegulationBI,
  title={Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils.},
  author={Hiroaki Niiro and Teruhisa Otsuka and Kenji Izuhara and Kunihiro Yamaoka and Keiko Ohshima and Tadashi Tanabe and Shuntaro Hara and Yoshiaki Nemoto and Yosuke Tanaka and Hitoshi Nakashima and Yoshiyuki Niho},
  journal={Blood},
  year={1997},
  volume={89 5},
  pages={
          1621-8
        }
}
Neutrophils are important effector cells of acute inflammation because of their potential capacity to synthesize various proinflammatory mediators, and inhibition of their production is expected to result in anti-inflammatory effects. In this study, we investigate the effects of the anti-inflammatory cytokines, interleukin-10 (IL-10) and IL-4, on prostanoid synthesis in human neutrophils. Neutrophils isolated from healthy donors constitutively produced a small amount of prostaglandin E2 (PGE2… CONTINUE READING

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