Regulation by interdomain communication of a headful packaging nuclease from bacteriophage T4

@inproceedings{GhoshKumar2011RegulationBI,
  title={Regulation by interdomain communication of a headful packaging nuclease from bacteriophage T4},
  author={Manjira Ghosh-Kumar and Tanfis I. Alam and Bonnie Draper and John D. Stack and Venigalla B. Rao},
  booktitle={Nucleic acids research},
  year={2011}
}
In genome packaging by tailed bacteriophages and herpesviruses, a concatemeric DNA is cut and inserted into an empty procapsid. A series of cuts follow the encapsidation of each unit-length 'headful' genome, but the mechanisms by which cutting is coupled to packaging are not understood. Here we report the first biochemical characterization of a headful… CONTINUE READING