Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes.

  title={Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes.},
  author={Olivier Fardel and Val{\'e}rie Lecureur and Andr{\'e} Guillouzo},
  journal={FEBS letters},
  volume={327 2},
We have examined P-glycoprotein (P-gp) expression and function in cultured rat hepatocytes in response to dexamethasone (DEX), which is known to modulate various liver functions. Northern blot analyses revealed high levels of P-gp mRNAs in cultured untreated liver cells in comparison to those found in freshly isolated hepatocytes, while DEX-treated hepatocytes also displayed elevated, although weaker, P-gp levels. Similarly, Western blotting analysis indicated high levels of P-gp in liver cells… CONTINUE READING

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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques • 2011
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