Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes.

@article{Belhassen1997RegulationBC,
  title={Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes.},
  author={L Belhassen and Olivier F{\'e}ron and David M. Kaye and Thomas Michel and Ralph A. Kelly},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 17},
  pages={11198-204}
}
Cardiac myocytes express the nitric-oxide synthase isoform originally identified in endothelial cells, termed eNOS or NOS3, where it plays a role in regulating myocyte responsiveness to both adrenergic and muscarinic cholinergic autonomic nervous system agonists. eNOS in endothelial cells has been shown to undergo extensive post-translational processing, and in cardiac myocytes as well as endothelial cells, eNOS has been shown to be targeted to plasmalemmal caveolae, a process that is dependent… CONTINUE READING
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