Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease.

  title={Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease.},
  author={Vishal R. Mali and Suresh Selvaraj Palaniyandi},
  journal={Free radical research},
  volume={48 3},
4-Hydroxy-2-nonenal (4-HNE), a reactive aldehyde, is generated from polyunsaturated fatty acids (PUFAs) in biological membranes. Reactive oxygen species (ROS) generated during oxidative stress react with PUFAs to form aldehydes like 4-HNE, which inactivates proteins and DNA by forming hybrid covalent chemical addition compounds called adducts. The ensuing chain reaction results in cellular dysfunction and tissue damage. It includes a wide spectrum of events ranging from electron transport chain… CONTINUE READING
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dysfunction: mechanistic signifi

  • H Esterbauer, RJ Schaur, H Zollner
  • Environ Mol Mutagen
  • 2010
Highly Influential
6 Excerpts

Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart

  • T Ishikawa, H Esterbauer, H Sies
  • J Biol Chem
  • 1998
Highly Influential
5 Excerpts

Eff ects of 4 - hydroxynonenal [ 66 ] on vascular endothelial and smooth muscle cell redox signaling and function in health and disease

  • J Ruef, M Moser, C Bode, W Kubler, MS Runge
  • Redox Biol
  • 2013

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