Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease.

@article{Mali2014RegulationAT,
  title={Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease.},
  author={Vishal R. Mali and Suresh Selvaraj Palaniyandi},
  journal={Free radical research},
  year={2014},
  volume={48 3},
  pages={251-63}
}
4-Hydroxy-2-nonenal (4-HNE), a reactive aldehyde, is generated from polyunsaturated fatty acids (PUFAs) in biological membranes. Reactive oxygen species (ROS) generated during oxidative stress react with PUFAs to form aldehydes like 4-HNE, which inactivates proteins and DNA by forming hybrid covalent chemical addition compounds called adducts. The ensuing chain reaction results in cellular dysfunction and tissue damage. It includes a wide spectrum of events ranging from electron transport chain… CONTINUE READING
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