Regulation and signaling of human bombesin receptors and their biological effects

@article{Weber2009RegulationAS,
  title={Regulation and signaling of human bombesin receptors and their biological effects},
  author={Horst Christian Weber},
  journal={Current Opinion in Endocrinology, Diabetes and Obesity},
  year={2009},
  volume={16},
  pages={66–71}
}
  • H. Weber
  • Published 1 February 2009
  • Biology, Chemistry, Medicine
  • Current Opinion in Endocrinology, Diabetes and Obesity
Purpose of reviewThis review will highlight recent advances in the understanding of molecular mechanisms by which mammalian bombesin receptors are regulated and which intracellular signaling pathways have been characterized to mediate agonist-dependent receptor biological effects. Recent findingsMammalian bombesin receptors have been demonstrated to be involved in a larger array of physiological and pathophysiological conditions than previously reported. Pharmacological experiments in vitro and… 
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59 Citations
Highly Influential Citations
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28
Methods Citations
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59 Citations

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Citation Type

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Novel pharmacological insights of bombesin-like peptides and the interaction with their respective receptors have been elucidated to aid future treatment and imaging of epithelial cell-derived tumors.
Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors
Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs
Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism.
Neuromedin B and Its Receptor Influence the Activity of Myometrial Primary Cells In Vitro Through Regulation of Il6 Expression via the Rela/p65 Pathway in Mice1
TLDR
Data demonstrated that the Nmb/Nmbr interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway, although the effects of Nmbr on [Ca2+]i involved several pathways that remain to be elucidated.
Its Receptor Influence the Activity of Myometrial Primary Cells In Vitro Through Regulation of Il 6 Expression via the Rela / p 65 Pathway in Mice 1
TLDR
Data demonstrated that the Nmb/Nmbr interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway, although the effects of Nmbr on [Ca] i involved several pathways that remain to be elucidated.
Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): Affinities, potencies and selectivity in multiple native and BnR transfected cells
Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells
TLDR
It is demonstrated that EVs contributed to the transfer of functional BRS-3 to the recipient cells, whose secretion was partially regulated by RhoA signaling pathway.
Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment
TLDR
Recent studies support the conclusion that Bn-peptides/BnRs are well-positioned for numerous novel antitumor treatments, including interrupting autocrine-growth and the use of over-expressed receptors for imaging and targeting cytotoxic-compounds, either by direct-coupling or combined with nanoparticle-technology.
Powerful inhibition of in-vivo growth of experimental hepatic cancers by bombesin/gastrin-releasing peptide antagonist RC-3940-II
TLDR
BN/GRP antagonist RC-3940-II powerfully inhibits growth of SK-Hep-1 and Hep-G2 cancers in nude mice and may be linked to changes in expression of those cancer genes important in angiogenesis, invasion, and metastasis.
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References

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    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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