Regulation and regulatory role of the retinoids.

  title={Regulation and regulatory role of the retinoids.},
  author={Kong Wah Ng and H. Mimi Zhou and Shehnaaz S M Manji and Thomas J Martin},
  journal={Critical reviews in eukaryotic gene expression},
  volume={5 3-4},
Retinoids regulate differentiation and cellular growth, exerting their physiological action by interacting with two families of nuclear receptors, the retinoic acid receptors (RARs), and the retinoid X receptors (RXRs), which regulate gene expression by forming transcriptionally active heterodimeric RAR/RXR or homodimeric RXR/RXR complexes on DNA. Although RAR/RXR heterodimers form preferentially in vitro and in vivo, it does not exclude the possibility that RXR/RXR homodimers may regulate a… CONTINUE READING