Regulation and possible role of mammalian phospholipase D in cellular functions.

@article{Banno2002RegulationAP,
  title={Regulation and possible role of mammalian phospholipase D in cellular functions.},
  author={Yoshiko Banno},
  journal={Journal of biochemistry},
  year={2002},
  volume={131 3},
  pages={
          301-6
        }
}
  • Y. Banno
  • Published 1 March 2002
  • Biology, Chemistry
  • Journal of biochemistry
Phospholipase D (PLD), an enzyme widely distributed in bacteria, fungi, plants, and animals, catalyzes the hydrolysis of phosphatidylcholine (PC) and other phospholipids to generate phosphatidic acid (PA). PLD activity can lead to the generation of phosphatidylalcohol in the presence of a primary alcohol. This reaction, referred to as transphosphatidylation, is not only a hallmark of PLD activity but has also been used to block the production of PA in functional studies. PLD activity in… 

Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei.

It is proposed that RA receptors coupled with PLA2, PLC, and PLD activities in the nucleus may play an important role in the redistribution of arachidonic acid and its metabolites and DAG in nuclear and non-nuclear neuronal membranes during differentiation and growth suppression.

The Molecular Basis of Phospholipase D2-Induced Chemotaxis: Elucidation of Differential Pathways in Macrophages and Fibroblasts

ABSTRACT We report the molecular mechanisms that underlie chemotaxis of macrophages and cell migration of fibroblasts, cells that are essential during the body's innate immune response and during

Metabolism and signaling activities of nuclear lipids

This review aims at highlighting the most important aspects regarding the metabolism and signaling activities of nuclear phosphatidylcholine, sphingomyelin, fatty acids and eicosanoids.

Phospholipase D Signaling and Extracellular Signal-Regulated Kinase-1 and -2 Phosphorylation (Activation) Are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation

It is demonstrated that inhibiting PLD signal generation with 1-butanol reduced TPA-stimulated transglutaminase activity, a marker of keratinocyte differentiation, and suggest the independent involvement of the PLD and ERK-1/2 pathways in mediating transglUTaminases activity and keratinocytes differentiation.

Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells.

Results show that, in S1P3-CHO cells, increased expression of PLDs prevents ActD-induced apoptosis by enhanced activation of the PI3K signalling pathways.

The structure and function of protein kinase C-related kinases (PRKs)

A holistic overview of the structure and function of PRKs is provided and the molecular events that govern activation and autoregulation of catalytic activity are described, including phosphorylation, protein interactions and lipid binding.

Targeting of Protein Kinase C-ϵ during Fcγ Receptor-dependent Phagocytosis Requires the ϵC1B Domain and Phospholipase C-γ1

A model in which PI-PLC-γ1 provides DAG that binds to eC1B, facilitating PKC-e localization to phagosomes for efficient IgG-mediated phagocytosis is supported.

Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells.

The results suggest that PLDs are involved in growth factor regulation of at least two signalling pathways, PI 3-kinase/Akt and ERKs, depending on the class of cell-surface receptors.