Regulation and possible role of mammalian phospholipase D in cellular functions.

  title={Regulation and possible role of mammalian phospholipase D in cellular functions.},
  author={Yoshiko Banno},
  journal={Journal of biochemistry},
  volume={131 3},
  • Y. Banno
  • Published 1 March 2002
  • Biology, Chemistry
  • Journal of biochemistry
Phospholipase D (PLD), an enzyme widely distributed in bacteria, fungi, plants, and animals, catalyzes the hydrolysis of phosphatidylcholine (PC) and other phospholipids to generate phosphatidic acid (PA). PLD activity can lead to the generation of phosphatidylalcohol in the presence of a primary alcohol. This reaction, referred to as transphosphatidylation, is not only a hallmark of PLD activity but has also been used to block the production of PA in functional studies. PLD activity in… 

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