Regulation and physiological functions of G12/13-mediated signaling pathways.

@article{Suzuki2009RegulationAP,
  title={Regulation and physiological functions of G12/13-mediated signaling pathways.},
  author={Nobuchika Suzuki and Nicole Hajicek and Tohru Kozasa},
  journal={Neuro-Signals},
  year={2009},
  volume={17 1},
  pages={
          55-70
        }
}
Accumulating data indicate that G12 subfamily (Galpha12/13)-mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant regulation of this pathway has been identified in various human diseases. It has been demonstrated that Galpha12/13-mediated signals form networks with other signaling proteins at various levels, from cell surface receptors to transcription factors, to regulate cellular responses. Galpha12/13 have slow rates of nucleotide exchange and… CONTINUE READING

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