Regulation and pathological role of p53 in cisplatin nephrotoxicity.

  title={Regulation and pathological role of p53 in cisplatin nephrotoxicity.},
  author={Man Jiang and Zheng Dong},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={327 2},
Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, its use is limited by side effects in normal tissues, particularly the kidneys. Recent studies, using both in vitro and in vivo experimental models, have suggested a critical role for p53 in cisplatin nephrotoxicity. The signaling pathways upstream and downstream of p53 are being investigated and related to renal cell injury and death. Along with the mechanistic studies, renoprotective approaches… CONTINUE READING