Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin.

@article{Rettig1993RegulationAH,
  title={Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin.},
  author={Wolfgang J. Rettig and Pilar Garin-Chesa and John H. Healey and Sai L. Su and Harvey L. Ozer and Michael Schwab and Anthony P. Albino and L. John Old},
  journal={Cancer research},
  year={1993},
  volume={53 14},
  pages={3327-35}
}
The human fibroblast activation protein (FAP), defined by monoclonal antibody F19, is expressed in vivo in reactive stromal fibroblasts of epithelial cancers, subsets of bone and soft tissue sarcomas, and granulation tissue of healing wounds. FAP is generally absent from the stroma of benign epithelial tumors and normal adult tissues. In vitro FAP induction is observed in proliferating cultured fibroblasts and in melanocytes grown with fibroblast growth factor and phorbol ester. In the present… CONTINUE READING
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Inhibition of the fibroblast growth factor receptor 1 ( FGFR - ll gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation

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