Regulation and functional characterization of a rat recombinant dopamine D3 receptor.

@article{Cox1995RegulationAF,
  title={Regulation and functional characterization of a rat recombinant dopamine D3 receptor.},
  author={Betty A. Cox and Mary P. Rosser and Michael R. Kozlowski and K M Duwe and Rachael Lee Neve and Kim A Neve},
  journal={Synapse},
  year={1995},
  volume={21 1},
  pages={1-9}
}
We stably expressed a rat D3 receptor cDNA in C6 glioma cells (C6-D3 cells), quantifying receptor expression with the radioligands [125I]epidepride (KD = 0.1 nM) and [3H]spiperone (KD = 0.7 nM). As reported previously for D2 receptors, quinpirole induced a 9-16% increase in the rate of extracellular acidification by C6-D3 cells. The acidification was inhibited by epidepride and by the Na+/H+ antiporter inhibitors, amiloride and methylisobutylamiloride, but pertussis toxin treatment had no… CONTINUE READING

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