Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.

@article{Magnuson2012RegulationAF,
  title={Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.},
  author={Brian Magnuson and Bilgen Ekim and D. Fingar},
  journal={The Biochemical journal},
  year={2012},
  volume={441 1},
  pages={
          1-21
        }
}
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating signals derived from diverse environmental cues to promote anabolic and inhibit catabolic cellular functions. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1 and S6K2, whose first identified substrate… Expand
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