Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor

@article{Dijkers1999RegulationAF,
  title={Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor},
  author={Pascale F. Dijkers and Thamar B. van Dijk and Rolf P. de Groot and J. G. A. M. Raaijmakers and Jan-Willem J Lammers and Leo Koenderman and Paul James Coffer},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={3334-3342}
}
Interleukin (IL)-3, IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) regulate proliferation, differentiation and apoptosis of target cells. Receptors for these cytokines consist of a cytokine-specific α subunit and a common shared βc subunit. Tyrosine phosphorylation of the βc is thought to play a critical role in mediating signal… CONTINUE READING