Regulation and function of proline oxidase under nutrient stress

  title={Regulation and function of proline oxidase under nutrient stress},
  author={Jui Pandhare and Steven P. Donald and Sandra K. Cooper and James M Phang},
  journal={Journal of Cellular Biochemistry},
Under conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP. This degradative pathway generates glutamate and α‐ketoglutarate… 
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