Regulation and function of proline oxidase under nutrient stress

@article{Pandhare2009RegulationAF,
  title={Regulation and function of proline oxidase under nutrient stress},
  author={Jui Pandhare and Steven P. Donald and Sandra K. Cooper and James M Phang},
  journal={Journal of Cellular Biochemistry},
  year={2009},
  volume={107}
}
Under conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP. This degradative pathway generates glutamate and α‐ketoglutarate… 
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References

SHOWING 1-10 OF 32 REFERENCES
Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers
TLDR
POX metabolism of substrate proline affects multiple signaling pathways, modulating both apoptosis and tumor growth, and could be an attractive target to metabolically control the cancer phenotypes.
Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
TLDR
Findings indicate that AMPK expression contributes to tolerance to nutrient starvation in cancer cells, and proposes AMPK as a new target for therapeutic strategies to suppress tumor growth and invasion.
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
The regulatory functions of proline and pyrroline-5-carboxylic acid.
  • J. Phang
  • Biology, Chemistry
    Current topics in cellular regulation
  • 1985
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.
TLDR
The AMPK cascade is the probable target for the antidiabetic drug metformin, and current indications are that it is responsible for many of the beneficial effects of exercise in the treatment and prevention of type 2 diabetes and the metabolic syndrome.
Autophagy in metazoans: cell survival in the land of plenty
TLDR
Despite evolving the ability to maintain a constant supply of extracellular nutrients, metazoans have retained a complete set of autophagy genes, and the physiological relevance ofautophagy in such species is just beginning to be explored.
5-amino-4-imidazolecarboxamide riboside confers strong tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent fashion.
TLDR
AICAR was found to confer strong tolerance to glucose starvation by using antisense RNA expression vector for alpha subunit of 5'-AMP-activated protein kinase containing the alpha2 subunit, indicating an energy source switch from glucose to amino acids.
Beginnings of a signal-transduction pathway for bioenergetic control of cell survival.
Fuel feeds function: energy metabolism and the T-cell response
TLDR
This Review describes how T cells actively acquire metabolic substrates from their environment to meet these energy demands and respond appropriately to pathogens.
...
...