Regulation and function of p38 protein kinase in isolated canine gastric parietal cells.

@article{Pausawasdi2000RegulationAF,
  title={Regulation and function of p38 protein kinase in isolated canine gastric parietal cells.},
  author={Nonthalee Pausawasdi and Saravanan Ramamoorthy and Vinzenz M Stepan and John Del Valle and Andrea Todisco},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={278 1},
  pages={
          G24-31
        }
}
We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were dose- and time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity… 
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18 Citations
Background Citations
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Methods Citations
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18 Citations

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Citation Type

Regulation and function of COX-2 gene expression in isolated gastric parietal cells.
TLDR
Carbachol induces COX-2 gene expression in the parietal cells through signaling pathways that involve intracellular Ca(2+), PKC, p38 kinase, and activation of NF-kappaB, and the functional significance of these effects seems to be stimulation of PGE(2) release.
p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells.
TLDR
It is concluded that Ca( 2+)-dependent agonists stimulate p38 MAPK in T(84) cells by a mechanism involving intracellular Ca(2+), Src family kinases, and the EGFR.
The Akt and MAPK signal-transduction pathways regulate growth factor actions in isolated gastric parietal cells.
TLDR
Activation of the Akt signal-transduction pathway seems to be a crucial event for the induction of parietal cell maturation and differentiation.
Role of Rho in rabbit parietal cell
TLDR
The finding that any treatment which inhibit Rho augment acid secretion whereas those that activate Rho inhibit secretion strongly suggests that the Rho‐pathway conducts a negatively regulating signal in parietal cell activation, possibly via site‐specific regulation of actin microfilaments.
p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability.
TLDR
It is indicated that constitutive p38 activity contributes to the low Na+ permeability necessary for maintenance of cell volume, and that recombinant p38 negatively modulates the set point for volume-sensitive channel opening.
Molecular mechanisms for the antiapoptotic action of gastrin.
TLDR
G17 promotes AR42J cell survival through the induction of Akt via PI 3-kinase and SB-203580-sensitive kinase activities via p38 kinase activity at doses and with kinetics similar to those observed for Akt induction.
Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation
TLDR
A resistance of p38α-deficient cells to C3-mediated inhibition of cell growth was indicated and this anti-proliferative effect was highly associated with the decreased activity of c-Jun and upstream p38 and JNK MAPK signaling as a consequence of the absence of p 38α.
Cell biology of acid secretion by the parietal cell.
TLDR
The early signaling events following histaminergic and cholinergic activation are reviewed, the identification of multiple factors participating in the trafficking and recycling of the proton pump, and the role of the cytoskeleton in supporting the apical pole remodeling, which appears to be necessary for active acid secretion by the parietal cell are reviewed.
Functional role of bone morphogenetic protein-4 in isolated canine parietal cells.
TLDR
BMP-4 promotes the induction and maintenance of a differentiated parietal cell phenotype through MAPK-dependent mechanisms and may provide new clues for a better understanding of the mechanisms that regulate gastric epithelial cell growth and differentiation.
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
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References

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