Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.

@article{Gabay2015RegulationAF,
  title={Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.},
  author={Cem Gabay and Jennifer E Towne},
  journal={Journal of leukocyte biology},
  year={2015},
  volume={97 4},
  pages={645-52}
}
IL-36α, IL-36β, and IL-36γ are members of the IL-1 family of cytokines that signal through a common receptor composed of IL-36R and IL-1R/AcP to activate NF-κB and MAPKs, such as p38 and JNK, and promote inflammatory responses. IL-36Ra is a natural antagonist of the 3 IL-36 agonists that binds to IL-36R and inhibits binding of the agonistic ligands. These cytokines are expressed predominantly by epithelial cells and act on a number of cells, including immune cells, epithelial cells, and… CONTINUE READING

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