Regulation and function of apoptosis signal‐regulating kinase 1 in rheumatoid arthritis

@article{Nygaard2018RegulationAF,
  title={Regulation and function of apoptosis signal‐regulating kinase 1 in rheumatoid arthritis},
  author={Gyrid Nygaard and Julie A. Di Paolo and Deepa R Hammaker and David L. Boyle and Grant R. Budas and Gregory T. Notte and Igor Mikaelian and Vivian Barry and Gary S. Firestein},
  journal={Biochemical Pharmacology},
  year={2018},
  volume={151},
  pages={282–290}
}
&NA; Despite improved therapy, rheumatoid arthritis (RA) remains an unmet medical need. Previous efforts to validate therapeutic targets in the mitogen‐activated protein kinase (MAPK) family have had minimal success. Therefore, we evaluated the potential for targeting an upstream MAPK, namely apoptosis signal‐regulating kinase 1 (ASK1), as an alternative approach. ASK1 protein and gene expression were observed in RA and osteoarthritis (OA) synovium as determined by immunohistochemistry (IHC… Expand
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