Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

@article{Kovaevi2017RegulationAC,
  title={Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.},
  author={Žaklina Kova{\vc}evi{\'c} and Sumit Sahni and Hiu Chuen Lok and Michael J Davies and David Anderson Wink and Des. R. Richardson},
  journal={Biochimica et biophysica acta},
  year={2017},
  volume={1861 5 Pt A},
  pages={995-999}
}
We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed… CONTINUE READING