Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

  title={Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.},
  author={Francisca E. Reyes-Turcu and Karen H Ventii and Keith D. Wilkinson},
  journal={Annual review of biochemistry},
Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene products, reverse the modification of proteins by a single ubiquitin(-like) protein, and remodel polyubiquitin(-like) chains on target proteins. The human genome encodes nearly 100 DUBs with specificity for ubiquitin in five gene families. Most DUB activity is cryptic, and conformational rearrangements often occur during the binding of ubiquitin and/or scaffold proteins. DUBs with specificity for… CONTINUE READING
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