Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans.

@article{Lemos2002RegulationAP,
  title={Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans.},
  author={Jos{\'e} A Lemos and Robert A Burne},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 22},
  pages={6357-66}
}
Tolerance of environmental stress, especially low pH, by Streptococcus mutans is central to the virulence of this organism. The Clp ATPases are implicated in the tolerance of, and regulation of the response to, stresses by virtue of their protein reactivation and remodeling activities and their capacity to target misfolded proteins for degradation by the ClpP peptidase. The purpose of this study was to dissect the role of selected clp genes in the stress responses of S. mutans, with a… CONTINUE READING
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