• Corpus ID: 82681533

Regulation and Pharmacological Manipulation of the Type 5 Metabotropic Glutamate (mGlu5) Receptor

@inproceedings{Bradley2011RegulationAP,
  title={Regulation and Pharmacological Manipulation of the Type 5 Metabotropic Glutamate (mGlu5) Receptor},
  author={Sophie J. Bradley},
  year={2011}
}
Coopman, K., Bradley, S.J., Wilkinson, G.F. and Willars, G.B. G-protein coupling and glucagonlike peptide-1 signalling in recombinant cell-lines. 2 Focused Meeting Cell Signalling 16-17 April 2007. Poster Presentation. Bradley, S.J., Howes, C.M., Wood, M.D. and Challiss, R.A.J. Effects of Positive Allosteric Modulators of the mGlu5 Receptor on Oscillatory Patterns of Ca 2+ Signalling. Metabotropic glutamate receptor conference Sicily 14-19 September 2008. Poster Presentation. Bradley, S.J… 

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TLDR
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TLDR
It is demonstrated that allosteric modulators can “tune” the Ca2+ oscillation frequency initiated by mGlu5 receptor activation, and this might allow pharmacological modification of the downstream processes (e.g., transcriptional regulation) that is unachievable through orthosteric ligand interactions.

The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

TLDR
It is demonstrated that mGluR5 is capable of inducing [Ca2+]i oscillations in cultured astrocytes and that phosphorylation/dephosphorylation of mGlamorganic glutamate receptor is critical in [Ca1+] i oscillations, analogous to the cloned mGLUR5 expressed in heterologous cell lines.
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