Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

@inproceedings{Grunnet2009RegulationAF,
  title={Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue},
  author={Louise G Grunnet and Emma Julia P. Nilsson and Charlotte Ling and Torben Hansen and Oluf Pedersen and Leif Groop and Allan Vaag and Pernille Poulsen},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism. RESEARCH DESIGN AND METHODS The FTO rs9939609 polymorphism was genotyped in two twin cohorts: 1) 298 elderly twins aged 62… CONTINUE READING
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