Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome a

@article{Beyreuther1993RegulationAE,
  title={Regulation and Expression of the Alzheimer's $\beta$/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome a},
  author={Konrad T. Beyreuther and Peter Pollwein and Gerd Multhaup and Ursula M{\"o}nning and Gerhard K{\"o}nig and Thomas Dyrks and Walter Schubert and Colin L. Masters},
  journal={Annals of the New York Academy of Sciences},
  year={1993},
  volume={695}
}
A four‐ to fivefold overexpression of the gene for the Alzheimer β/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS compared to the normal population. It is therefore likely that a deregulated overexpression of the APP gene is a risk factor for the β/A4 amyloid formation. To test this hypothesis and to get a better understanding of how APP expression is regulated, we… 
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