Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers

@inproceedings{Morgan2016RegulationMO,
  title={Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers},
  author={J. Morgan},
  year={2016}
}
In the work described in this thesis, analytical methods for the detection and quantification of peptide hormones featuring on-line analyte concentration, postseparation tagging and HPLC-fluorescence detection were presented. These methods were used to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysineextended CT (CTGKK), glycyllysine-extended CT (CTGK) and glycine-extended CT (CTG) for the first time, in DMS53 small cell lung carcinoma (SCLC) cell culture medium and… Expand