Regulation, integrase-dependent excision, and horizontal transfer of genomic islands in Legionella pneumophila.

@article{Lautner2013RegulationIE,
  title={Regulation, integrase-dependent excision, and horizontal transfer of genomic islands in Legionella pneumophila.},
  author={Monika Lautner and Eva Schunder and Vroni Herrmann and Klaus Heuner},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 7},
  pages={1583-97}
}
Legionella pneumophila is a Gram-negative freshwater agent which multiplies in specialized nutrient-rich vacuoles of amoebae. When replicating in human alveolar macrophages, Legionella can cause Legionnaires' disease. Recently, we identified a new type of conjugation/type IVA secretion system (T4ASS) in L. pneumophila Corby (named trb-tra). Analogous versions of trb-tra are localized on the genomic islands Trb-1 and Trb-2. Both can exist as an episomal circular form, and Trb-1 can be… CONTINUE READING