Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen.

@article{KhalkhaliEllis2004RegulatingTT,
  title={Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen.},
  author={Zhila Khalkhali-Ellis and Abby L Christian and Dawn A. Kirschmann and Elijah M Edwards and Maryam Rezaie-Thompson and Mohammad A. Vasef and Lynn M. Gruman and Richard E. B. Seftor and Laura E Norwood and Mary J. C. Hendrix},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 2},
  pages={449-54}
}
PURPOSE Mammary epithelial cells and the majority of breast cancer tumors require estrogen for continued growth. Antiestrogen therapy alone, or in combination with other drugs, has long been a common procedure for breast cancer treatment and prophylaxis. Thus, there is a critical need to elucidate the mechanism(s) of action of antiestrogen treatment, especially for patients who are at risk of breast cancer development or who are currently receiving hormone therapy. In this study, we examined… CONTINUE READING