Regulating the total level of a signaling protein can vary its dynamics in a range from switch like ultrasensitivity to adaptive responses.

@article{Soyer2009RegulatingTT,
  title={Regulating the total level of a signaling protein can vary its dynamics in a range from switch like ultrasensitivity to adaptive responses.},
  author={Orkun S. Soyer and Hiroyuki Kuwahara and Attila Csik{\'a}sz-Nagy},
  journal={The FEBS journal},
  year={2009},
  volume={276 12},
  pages={3290-8}
}
Biological signaling networks can exhibit rich response dynamics including ultrasensitivity, adaptation to persistent stimuli and oscillations. Previous modeling efforts have considered the proteins in these networks as two-state entities and their total levels as fixed quantities. However, inside the cell, most molecules are in constant flux because of… CONTINUE READING