Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP

@article{Suzuki1991RegulatingTR,
  title={Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP},
  author={Carolyn K. Suzuki and Juan S Bonifacino and Albert Yu-Min Lin and Mark M. Davis and Richard D. Klausner},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={114},
  pages={189 - 205}
}
Immunoglobulin heavy chain binding protein (BiP, GRP 78) coprecipitates with soluble and membrane-associated variants of the T-cell antigen receptor alpha chain (TCR-alpha) which are stably retained within the ER. Chelation of Ca2+ during solubilization of cells leads to the dissociation of BiP from the TCR-alpha variants, which is dependent upon the availability of Mg2+ and hydrolyzable ATP; this suggests that Ca2+ levels can serve to modulate the association/dissociation of these proteins… CONTINUE READING
50 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

A peptide sequence

  • Bonifacino, S J.
  • 1990

Cal ' imaging in single living cells : theoretical and practical issues

  • M. Yu, T. K. Ghosh, D. L. Gill
  • Cell Calcium .
  • 1990

Developmental regulation of IgM secretion : the role of the carboxy - terminal cysteine

  • F. Maley
  • 1990

Expressio n ofT cell antigen receptor heterodimers in a lipid - linked form

  • J. Lippincott-Schwartz, J. S. Bonifacino, L. C. Yuan, R. D. Klausner
  • Science ( Wash . DC ) .
  • 1990

Heav y chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein

  • Machamer, . C.E, R . W . Doms, D . G. Bole, A . Helenius, . J.K.Rose
  • J. Biol. Chem. 265 :68796883 .
  • 1990

Similar Papers

Loading similar papers…