Regulating the onset of mitosis.

  title={Regulating the onset of mitosis.},
  author={Ryoma Ohi and Kathleen L. Gould},
  journal={Current opinion in cell biology},
  volume={11 2},
In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition… CONTINUE READING