Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners

@article{Steinberg2009RegulatingTM,
  title={Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners},
  author={Marcos W. Steinberg and Jr-Wen Shui and Carl F Ware and Mitchell Kronenberg},
  journal={Seminars in Immunopathology},
  year={2009},
  volume={31},
  pages={207-221}
}
LIGHT and herpes virus entry mediator (HVEM) comprise a ligand–receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin β receptor, and HVEM can act as a ligand for immunoglobulin family molecules, including B- and T-lymphocyte attenuator, which suppresses immune responses. Complexity in this pivotal system arises from several factors, including the non… CONTINUE READING
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