Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation

@article{Wright2014RegulatingTL,
  title={Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation},
  author={John L. Wright and Richard A. Kahn and Elizabeth Sztul},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={71},
  pages={3419-3438}
}
Abstract Eukaryotic cells require selective sorting and transport of cargo between intracellular compartments. This is accomplished at least in part by vesicles that bud from a donor compartment, sequestering a subset of resident protein “cargos” destined for transport to an acceptor compartment. A key step in vesicle formation and targeting is the recruitment of specific proteins that form a coat on the outside of the vesicle in a process requiring the activation of regulatory GTPases of the… CONTINUE READING

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