Regulating the immune response to tumours.

  title={Regulating the immune response to tumours.},
  author={Gareth J. Betts and Sarah L. Clarke and Hannah E. Richards and Andrew J. Godkin and Awen Gallimore},
  journal={Advanced drug delivery reviews},
  volume={58 8},
Naturally occurring regulatory T cells (Tregs) have been shown to suppress immune responses to self-antigens, thereby limiting autoimmunity. In the case of tumours, where immune responses to self-antigens are beneficial and lead to elimination of the tumour, such suppressive activity is actually detrimental to the host. Manipulation of Tregs holds great promise for the immunotherapy of cancer. Several studies performed using rodent models and indicate that Tregs cells inhibit effective anti… CONTINUE READING

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