Regulating the genome surveillance system: miRNAs and the p53 super family

@article{Bailey2010RegulatingTG,
  title={Regulating the genome surveillance system: miRNAs and the p53 super family},
  author={Sarah G. Bailey and Tilman Sanchez-Elsner and Anastasis Stephanou and Mark S Cragg and Paul A. Townsend},
  journal={Apoptosis},
  year={2010},
  volume={15},
  pages={541-552}
}
The p53 gene super family consists of three members; TP53, TP63 and TP73, encoding proteins p53, p63 and p73. Whilst p63 appears to have an essential role in embryonic development with a less clear role in carcinogenesis, irregularities in p53 and p73 signalling are implicated in tumour formation. As such, p53 is a tumour suppressor which is mutated in over 50% cancers and p73 was recently formally classified as a tumour suppressor based on data showing p73 deficient mice generate spontaneous… CONTINUE READING