Regulating regulatory T cells to achieve transplant tolerance.

  title={Regulating regulatory T cells to achieve transplant tolerance.},
  author={Ran Tao and Wayne W Hancock},
  journal={Hepatobiliary & pancreatic diseases international : HBPD INT},
  volume={6 4},
BACKGROUND Regulatory T cells (Tregs) play crucial roles in both induction and maintenance of tolerance. This active immune regulation may contribute not only to the control of immune responses to self-antigens and thereby prevent autoimmune diseases, but also the control of responses to non-self molecules in adaptive immunity. Numerous experimental and clinical studies indicate that manipulating the balance between regulatory and responder T cells is an effective strategy to control immune… CONTINUE READING

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