Regulating leukotriene synthesis: The role of nuclear 5‐lipoxygenase

@article{Brock2005RegulatingLS,
  title={Regulating leukotriene synthesis: The role of nuclear 5‐lipoxygenase},
  author={T. Brock},
  journal={Journal of Cellular Biochemistry},
  year={2005},
  volume={96}
}
  • T. Brock
  • Published 2005
  • Biology, Medicine
  • Journal of Cellular Biochemistry
Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium‐mediated movement of enzymes, including 5‐lipoxygenase, to intracellular membranes. However, 5‐lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular… Expand
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