Regulating gene expression with light-activated oligonucleotides.

  title={Regulating gene expression with light-activated oligonucleotides.},
  author={Xinjing Tang and Ivan J Dmochowski},
  journal={Molecular bioSystems},
  volume={3 2},
Since the development of light-responsive amino acids, the activity of numerous biomolecules has been photomodulated in biochemical, biophysical, and cellular assays. Biological problems of even greater complexity motivate the development of quantitative methods for controlling gene activity with high spatial and temporal resolution, using light as an external trigger. Photoresponsive DNA and RNA oligonucleotides would optimally serve this purpose, but have proven difficult to expand from… CONTINUE READING


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