Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis

@article{Baudat2007RegulatingDD,
  title={Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis},
  author={F. Baudat and B. Massy},
  journal={Chromosome Research},
  year={2007},
  volume={15},
  pages={565-577}
}
During meiosis the programmed induction of DNA double-stranded breaks (DSB) leads to crossover (CO) and non-crossover products (NCO). One key role of CO is to connect homologs before metaphase I and thus to ensure the proper reductional segregation. This role implies an accurate regulation of CO frequency with the establishment of at least one CO per chromosome arm. Current major challenges are to understand how CO and NCO formation are regulated and what is the role of NCO. We present here the… Expand
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