Regulating angiogenesis at the level of PtdIns-4,5-P2.

@article{Im2006RegulatingAA,
  title={Regulating angiogenesis at the level of PtdIns-4,5-P2.},
  author={Eunok Im and Algirdas Kazlauskas},
  journal={The EMBO journal},
  year={2006},
  volume={25 10},
  pages={
          2075-82
        }
}
Angiogenesis is a coordinated sequence of cellular responses that result in the outgrowth of new blood vessels. The angiogenic program is regulated by extracellular factors, whose input is integrated at least in part at the level of signal transduction pathways driven by phosphoinositide 3 kinase (PI3K) and phospholipase Cgamma (PLCgamma). Using an in vitro angiogenesis model, we discovered that PI3K was essential for tube formation, whereas PLCgamma promoted regression. The underlying… CONTINUE READING
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