Regulating PPARδ signaling as a potential therapeutic strategy for skeletal muscle disorders in heart failure.

@article{Myers2015RegulatingPS,
  title={Regulating PPARδ signaling as a potential therapeutic strategy for skeletal muscle disorders in heart failure.},
  author={Ronald B. Myers and Jun Yoshioka},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2015},
  volume={308 9},
  pages={H967-9}
}
DESPITE REMARKABLE improvements in cardiac mortality rates during the past decades (4), poor quality of life remains a major concern for patients with heart failure. One of the determinants of quality of life is exercise tolerance (6). Limited exercise capacity can result from multiple abnormalities in heart failure, which include changes in intramuscular metabolism (20, 21, 28, 46), local inflammatory response (35), vascular endothelial dysfunction (9), insulin resistance (38), and altered… CONTINUE READING

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