Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells

@inproceedings{Eldeeb2018RegulatingAB,
  title={Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells},
  author={Mohamed A Eldeeb and Richard Peter Fahlman and Mansoore Esmaili and Mohamed Abdel Salam Ragheb},
  booktitle={International journal of molecular sciences},
  year={2018}
}
A pivotal hallmark of some cancer cells is the evasion of apoptotic cell death. Importantly, the initiation of apoptosis often results in the activation of caspases, which, in turn, culminates in the generation of proteolytically-activated protein fragments with potentially new or altered roles. Recent investigations have revealed that the activity of a significant number of the protease-generated, activated, pro-apoptotic protein fragments can be curbed via their selective degradation by the N… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 153 REFERENCES

Caspase functions in cell death and disease.

  • Cold Spring Harbor perspectives in biology
  • 2015
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Cell Death Signaling.

  • Cold Spring Harbor perspectives in biology
  • 2015
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

Heon-Ki Kim, Ryu-Ryun Kim, +3 authors Cheol-Sang Hwang
  • Cell
  • 2014
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

The DegraBase: a database of proteolysis in healthy and apoptotic human cells.

  • Molecular & cellular proteomics : MCP
  • 2013
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Human caspases: activation, specificity, and regulation.

  • The Journal of biological chemistry
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

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