Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

@inproceedings{Soares2013RegulatedVF,
  title={Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse},
  author={Helena Soares and Ricardo Henriques and Martin Sachse and Leandro N. Ventimiglia and Miguel Angel Verdugo Alonso and Christophe Zimmer and M I Thoulouze and Andr{\'e}s Alcover},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
How the vesicular traffic of signaling molecules contributes to T cell receptor (TCR) signal transduction at the immunological synapse remains poorly understood. In this study, we show that the protein tyrosine kinase Lck, the TCRζ subunit, and the adapter LAT traffic through distinct exocytic compartments, which are released at the immunological synapse in a differentially regulated manner. Lck vesicular release depends on MAL protein. Synaptic Lck, in turn, conditions the calcium- and… CONTINUE READING

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