Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.

@article{Daniels1999RegulatedTO,
  title={Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.},
  author={Gwynn Marie Daniels and Susan Gaye Amara},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 50},
  pages={
          35794-801
        }
}
The dopamine transporter plays an essential role in the modulation of dopaminergic neurotransmission by mediating the reuptake of dopamine into presynaptic neurons. In cells expressing the dopamine transporter, activation of protein kinase C by phorbol esters results in a significant reduction in dopamine uptake. This phorbol ester-mediated inhibition of dopamine transport is associated with a decrease in V(max), although the apparent affinity of the transporter for dopamine remains unchanged… CONTINUE READING
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