Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.

@article{Baek2003RegulatedSO,
  title={Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.},
  author={Sung Hee Baek and Chrissa Kioussi and Paola Briata and Degeng Wang and Hung Nguyen and Kenneth a. Ohgi and Christopher K. Glass and Anthony Wynshaw-Boris and David W. Rose and Michael G. Rosenfeld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 6},
  pages={
          3245-50
        }
}
Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2. Here, we report that Pitx2, in response to the Wntbeta-catenin pathway and growth signals, also can regulate c-Myc and cyclin D1. Investigation of molecular mechanisms required for Pitx2-dependent proliferation, in these cases, further supports a nuclear role for beta-catenin in preventing the histone deacetylase 1… CONTINUE READING

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