Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan

@inproceedings{Muro2003RegulatedSO,
  title={Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan},
  author={Andr{\'e}s F Muro and Anil K Chauhan and Sre{\'c}ko Gajovi{\'c} and Alessandra Iaconcig and Fabiola Porro and Giorgio Stanta and Francisco E. Baralle},
  booktitle={The Journal of cell biology},
  year={2003}
}
Fibronectins (FNs) are multifunctional high molecular weight glycoproteins present in the blood plasma and in the ECMs of tissues. The FN primary transcript undergoes alternative splicing in three regions generating up to 20 main different variants in humans. However, the precise role of the FN isoforms is poorly understood. One of the alternatively spliced exons is the extra domain A (EDA) or extra type III homology that is regulated spatially and temporally during development and aging. To… CONTINUE READING

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