Regulated secretion of complement factor H by RPE and its role in RPE migration

  title={Regulated secretion of complement factor H by RPE and its role in RPE migration},
  author={Yeong Hoon Kim and Shikun He and Satoru Kase and Mizuki Kitamura and Stephen J. Ryan and David R Hinton},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
Variants in the gene for complement factor H (CFH) have been implicated as a major risk factor for the development of age-related macular degeneration (AMD). Little is known, however, about the factors regulating local expression and secretion of CFH by retinal pigment epithelial cells (RPE). Cultured human early passage RPE cells, highly differentiated, polarized human RPE cultures, and bovine RPE explants were incubated in the presence or absence of recombinant human or bovine interferon… CONTINUE READING


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the genome yields an important clue

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