Regulated recruitment and cooperativity in the design of biological regulatory systems.

  title={Regulated recruitment and cooperativity in the design of biological regulatory systems.},
  author={Mark Ptashne},
  journal={Philosophical transactions. Series A, Mathematical, physical, and engineering sciences},
  volume={361 1807},
  • Mark Ptashne
  • Published 2003 in
    Philosophical transactions. Series A…
What distinguishes a man from a mouse is not so much different proteins, but rather the appearance of common proteins (etc.) at different times and positions in the developing organisms. Thus specific genes are transcribed or repressed, proteins degraded or stabilized, RNA transcripts spliced one way or another, and so on. These are examples of 'regulatory' decisions. A rather simple mechanism - called regulated recruitment - lies at the heart of many of these regulatory decisions. 

From This Paper

Figures, tables, and topics from this paper.
9 Citations
5 References
Similar Papers


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-5 of 5 references

Genes and signals

  • M. Ptashne, A. Gann
  • Cold Spring Harbor,
  • 2002
Highly Influential
7 Excerpts

A genetic switch: phage lambda and higher organisms, 2nd edn

  • M. Ptashne
  • 1992
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…