Regulated recruitment and cooperativity in the design of biological regulatory systems.

@article{Ptashne2003RegulatedRA,
  title={Regulated recruitment and cooperativity in the design of biological regulatory systems.},
  author={Mark Ptashne},
  journal={Philosophical transactions. Series A, Mathematical, physical, and engineering sciences},
  year={2003},
  volume={361 1807},
  pages={1223-34}
}
  • Mark Ptashne
  • Published 2003 in
    Philosophical transactions. Series A…
What distinguishes a man from a mouse is not so much different proteins, but rather the appearance of common proteins (etc.) at different times and positions in the developing organisms. Thus specific genes are transcribed or repressed, proteins degraded or stabilized, RNA transcripts spliced one way or another, and so on. These are examples of 'regulatory' decisions. A rather simple mechanism - called regulated recruitment - lies at the heart of many of these regulatory decisions. 

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