Regulated proteolysis of the alternative sigma factor SigX in Streptococcus mutans: implication in the escape from competence

@inproceedings{Dong2014RegulatedPO,
  title={Regulated proteolysis of the alternative sigma factor SigX in Streptococcus mutans: implication in the escape from competence},
  author={Gaofeng Dong and Xiao-Lin Tian and Zubelda A Gomez and Yung-Hua Li},
  booktitle={BMC Microbiology},
  year={2014}
}
SigX (σX), the alternative sigma factor of Streptococcus mutans, is the key regulator for transcriptional activation of late competence genes essential for taking up exogenous DNA. Recent studies reveal that adaptor protein MecA and the protease ClpC act as negative regulators of competence by a mechanism that involves MecA-mediated proteolysis of SigX by the ClpC in S. mutans. However, the molecular detail how MecA and ClpC negatively regulate competence in this species remains to be… CONTINUE READING
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