Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins.

@article{Blakely1998RegulatedPA,
  title={Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins.},
  author={Randy D. Blakely and Sammanda Ramamoorthy and Sally Schroeter and Yan Qian and Subramaniam Apparsundaram and Aurelio Galli and Louis J. DeFelice},
  journal={Biological psychiatry},
  year={1998},
  volume={44 3},
  pages={169-78}
}
Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERTs) mediate antidepressant-sensitive clearance of 5-HT following release. Although we have been aware for decades that SERT-mediated 5-HT clearance can be modulated by exogenous agents including serotonin-selective reuptake inhibitors, amphetamines, and cocaine, we have had little reason to speculate that SERT activity was actively controlled through endogenous pathways. Recent studies indicate that SERTs are likely to be… CONTINUE READING

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