Regulated overexpression of heat shock protein 72 protects Madin-Darby canine kidney cells from the detrimental effects of high urea concentrations.

@article{Neuhofer2001RegulatedOO,
  title={Regulated overexpression of heat shock protein 72 protects Madin-Darby canine kidney cells from the detrimental effects of high urea concentrations.},
  author={Wolfgang Neuhofer and K Lugmayr and Maria Luisa Fraek and Franz-X. Beck},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 12},
  pages={2565-71}
}
Exposure of renal medullary cells to elevated extracellular NaCl concentrations is associated with increased heat shock protein 72 (HSP72) expression and improved resistance to subsequent exposure to a high urea concentration (600 mM). To establish a causal relationship between HSP72 expression and protection against high urea concentrations, HSP72 was… CONTINUE READING